2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

Related Products

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS09517
    NPY4R Human Pre-designed siRNA Set A
    		Inhibitor

    NPY4R Human Pre-designed siRNA Set A contains three designed siRNAs for NPY4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    NPY4R Human Pre-designed siRNA Set A
    NPY4R Human Pre-designed siRNA Set A
  • HY-RS09518
    Npy4r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Npy4r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy4r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy4r Mouse Pre-designed siRNA Set A
    Npy4r Mouse Pre-designed siRNA Set A
  • HY-RS09522
    Npy5r Rat Pre-designed siRNA Set A
    		Inhibitor

    Npy5r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy5r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy5r Rat Pre-designed siRNA Set A
    Npy5r Rat Pre-designed siRNA Set A
  • HY-129317
    A457
    		Antagonist
    A457 is a prokineticin receptor PKR2 antagonist, with an IC50 of 102 nM. A457 can rescue the cell surface expression and function of P290S PKR2, but not W178S and G234D PKR2.
    A457
  • HY-P5765
    Galanin (1-13)-spantide I
    		Antagonist
    Galanin (1-13)-spantide I is a chimeric peptide composed of the N-terminal fragment of galanin (amino acids 1-13) and spantide, a known substance P receptor antagonist. Galanin (1-13)-spantide I has a high affinity for spinal galanin receptor (Kd=1.16 nM). Galanin (1-13)-spantide I can be used to study the effects of galanin on feeding behavior.
    Galanin (1-13)-spantide I
  • HY-P3691
    CART (1-39), Human, Rat
    CART (1-39), Human, Rat is a neuropeptide consisting of 1-39 residues of the CART peptide. CART (1-39), Human, Rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (1-39), Human, Rat inhibits both normal and starvation-induced feeding. CART (1-39), Human, Rat can induce anxiety and stress-related behavior.
    CART (1-39), Human, Rat
  • HY-103536
    Galnon
    		Agonist
    Galnon is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon exhibits anticonvulsant and anxiolytic effects.
    Galnon
  • HY-110107
    GW438014A
    		Antagonist 99.98%
    GW438014A is a potent and selective NPY-Y5 receptor antagonist. GW438014A inhibits food intake and reduces body weight gain in obese rodents.
    GW438014A
  • HY-P1129
    AR-M1896
    		Agonist
    AR-M1896 is a GalR2 selective agonist with a binding IC50 of 1.76 nM for rat GalR2. AR-M1896 can be used for the research of acute myocardial infarction and neuropathic pain.
    AR-M1896
  • HY-P1249
    Neuropeptide SF(mouse,rat)
    		Agonist
    Neuropeptide SF (mouse,rat) is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .
    Neuropeptide SF(mouse,rat)
  • HY-P3212A
    Allo-aca TFA
    		Agonist
    Allo-aca TFA, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca TFA blocks leptin signaling and action in numerous in vitro and in vivo models.
    Allo-aca TFA
  • HY-P1250A
    RFRP-3(human) TFA
    		Agonist
    RFRP-3 (Neuropeptide VF(124-131))(human) TFA, a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.
    RFRP-3(human) TFA
  • HY-P3692
    CART (55-76), rat
    CART (55-76), rat is a neuropeptide (55-76 residues of the CART peptide) and constitutes the N-terminal fragments of CART (55-102). CART (55-76), rat is a rat satiety factor with potent appetite-suppressing activity and is closely associated with leptin and neuropeptide Y. CART (55-76), rat can induce anxiety and stress-related behavior.
    CART (55-76), rat
  • HY-RS09513
    Npy1r Rat Pre-designed siRNA Set A
    		Inhibitor

    Npy1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy1r Rat Pre-designed siRNA Set A
    Npy1r Rat Pre-designed siRNA Set A
  • HY-P1133
    Galanin (2-29) (rat)
    		Agonist
    Galanin (2-29) (rat) inhibits rat pancreatic protein and CCK-8-stimulated amylase secretion. Galanin (2-29) (rat) is an GAL2R agonist (Ki: 3.5 nM).
    Galanin (2-29) (rat)
  • HY-115575
    tBPC
    		Modulator
    tBPC is a selective positive allosteric modulator for human Y4 receptor (Y4R), which enhances the activation of Y4R in G protein signaling and arrestin3 recruitment.
    tBPC
  • HY-P5054
    Galanin (1-13)-Neuropeptide Y (25-36) amide
    		Agonist
    Galanin (1-13)-Neuropeptide Y (25-36) amide is a high-affinity ligand for galanin receptors, and galanin itself.
    Galanin (1-13)-Neuropeptide Y (25-36) amide
  • HY-P3676
    Neuropeptide Y (3-36) (porcine)
    		Agonist
    Neuropeptide Y (3-36) (porcine) is an agonist of neuropeptide Y (NPY) receptor subtype Y2, and stimulates feeding in rats. Neuropeptide Y (3-36) (porcine) is a highly Y2 selective ligand compared with nselective Y1/Y2 receptor ligand, Neuropeptide Y 1-36.
    Neuropeptide Y (3-36) (porcine)
  • HY-P1840A
    Galanin Receptor Ligand M35 TFA
    		Antagonist
    Galanin Receptor Ligand M35 TFA is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 TFA exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively.
    Galanin Receptor Ligand M35 TFA
  • HY-P5063
    Galanin-Like Peptide (human)
    Galanin-Like Peptide (human) is a 60 amino acid neuropeptide. Galanin-Like Peptide (human) plays an important role in the regulation of feeding, body weight and energy metabolism.
    Galanin-Like Peptide (human)
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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